Drug reference
posaconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Anti Fungals (Azoles)
Mechanism of action
Inhibits fungal cell membrane sterol biosynthesis
Common side effects
- Rash
- Vomiting
- Headache
- Nausea
- Hypokalemia
- Pyrexia
- Diarrhea
Contraindications
- Delayed-release oral suspension only Patients with known or suspected hereditary fructose intolerance (HFI)
- Hypersensitivity to posaconazole or other azoles Coadministration with sirolimus; increases sirolimus blood concentrations by ~9-fold CYP3A4 substrates that prolong the QT interval (eg, pimozide, quinidine) Coadministration with the HMG-CoA reductase inhibitors (statins) that are primarily…
Known interactions (16)
- avanafil + posaconazole Contraindicated
- dronedarone + posaconazole Contraindicated
- flibanserin + posaconazole Contraindicated
- posaconazole + simvastatin Contraindicated
- bromocriptine + posaconazole Major
- buprenorphine + posaconazole Major
- citalopram + posaconazole Major
- clozapine + posaconazole Major
- colchicine + posaconazole Major
- crizotinib + posaconazole Major
- efavirenz + posaconazole Major
- posaconazole + rifampin Major
- alfuzosin + posaconazole Moderate
- aripiprazole + posaconazole Moderate
- asenapine + posaconazole Moderate
- haloperidol + posaconazole Moderate
Related conditions
Frequently asked questions
What drug class is posaconazole?
posaconazole belongs to: Anti Fungals.
How does posaconazole work?
Inhibits fungal cell membrane sterol biosynthesis
What are the common side effects of posaconazole?
Rash, Vomiting, Headache, Nausea, Hypokalemia, Pyrexia, Diarrhea
Which drugs interact with posaconazole?
avanafil, dronedarone, flibanserin, simvastatin, bromocriptine, buprenorphine, citalopram, clozapine, colchicine, crizotinib, efavirenz, rifampin, alfuzosin, aripiprazole, asenapine
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