Drug interactions
Aluminum hydroxide + Quinidine
Severity: Moderate
Aluminum hydroxide and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Urinary alkalinization decreases renal clearance of quinidine and can increase serum levels. Because quinidine has a narrow therapeutic index and can prolong the QT interval, higher exposure may raise the risk of arrhythmia. Aluminum hydroxide alkalinizes urine only weakly, but the combination still warrants attention.
What this interaction means in plain words
Aluminum hydroxide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Quinidine belongs to Anti Parasitic.
Why it happens
Alkaline urine increases passive tubular reabsorption of quinidine, reducing its renal elimination.
What to do
Monitor ECG (QT interval) and quinidine levels when antacid use is regular or changes. Adjust the quinidine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
Frequently asked questions
Can I take Aluminum hydroxide with Quinidine?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Urinary alkalinization decreases renal clearance of quinidine and can increase serum levels. Because quinidine has a narrow therapeutic index and can prolong the QT interval, higher exposure may raise the risk of arrhythmia. Aluminum hydroxide alkalinizes urine only weakly, but the combination still warrants attention.
How serious is the interaction between Aluminum hydroxide and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (QT interval) and quinidine levels when antacid use is regular or changes. Adjust the quinidine dose as needed.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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