Drug interactions
Aluminum hydroxide + Sofosbuvir-velpatasvir
Severity: Moderate
Aluminum hydroxide and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids raise gastric pH, and velpatasvir is poorly soluble at higher pH. Absorption may fall and reduce antiviral efficacy.
What this interaction means in plain words
Aluminum hydroxide and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Increased gastric pH decreases velpatasvir solubility and absorption.
What to do
Separate antacid and sofosbuvir-velpatasvir doses by at least 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids raise gastric pH, and velpatasvir is poorly soluble at higher pH. Absorption may fall and reduce antiviral efficacy.
How serious is the interaction between Aluminum hydroxide and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate antacid and sofosbuvir-velpatasvir doses by at least 4 hours.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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