Drug interactions
Amantadine + Quinidine
Severity: Moderate
Amantadine and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine reduces the renal clearance of amantadine, raising its plasma levels. This may increase amantadine adverse effects such as confusion, hallucinations, dizziness and myoclonus, especially in older patients or those with impaired renal function.
What this interaction means in plain words
Amantadine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Quinidine belongs to Anti Parasitic.
Why it happens
Inhibition of renal tubular cationic secretion of amantadine.
What to do
Monitor for amantadine toxicity such as neurotoxicity and consider reducing the amantadine dose, particularly in renal impairment or elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Amantadine with Quinidine?
MediHelp rates the interaction as moderate. Amantadine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine reduces the renal clearance of amantadine, raising its plasma levels. This may increase amantadine adverse effects such as confusion, hallucinations, dizziness and myoclonus, especially in older patients or those with impaired renal function.
How serious is the interaction between Amantadine and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for amantadine toxicity such as neurotoxicity and consider reducing the amantadine dose, particularly in renal impairment or elderly patients.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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