Drug interactions
Amantadine + Tiotropium
Severity: Minor
Amantadine and Tiotropium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amantadine has anticholinergic properties that may add to the effects of inhaled tiotropium. This can increase dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients.
What this interaction means in plain words
Amantadine and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amantadine belongs to Anti Virals; Tiotropium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects through pharmacodynamic synergism.
What to do
Monitor for urinary retention, constipation and confusion in elderly or prostatic patients. Reduce the dose or reassess therapy if anticholinergic symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tiotropium
Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Tiotropium?
MediHelp rates the interaction as minor. Amantadine and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amantadine has anticholinergic properties that may add to the effects of inhaled tiotropium. This can increase dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients.
How serious is the interaction between Amantadine and Tiotropium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and confusion in elderly or prostatic patients. Reduce the dose or reassess therapy if anticholinergic symptoms emerge.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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