Drug interactions
Amifampridine + Bupropion
Severity: Moderate
Amifampridine and Bupropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower the seizure threshold, so using them together may raise the likelihood of seizures. This is relevant because amifampridine already carries a dose-related seizure risk and bupropion is itself dose-dependently epileptogenic.
What this interaction means in plain words
Amifampridine and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Bupropion belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic lowering of seizure threshold.
What to do
Avoid the combination in patients with a seizure history or other risk factors. If both are needed, keep both at the lowest effective doses and counsel patients and caregivers on seizure precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Bupropion?
MediHelp rates the interaction as moderate. Amifampridine and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower the seizure threshold, so using them together may raise the likelihood of seizures. This is relevant because amifampridine already carries a dose-related seizure risk and bupropion is itself dose-dependently epileptogenic.
How serious is the interaction between Amifampridine and Bupropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a seizure history or other risk factors. If both are needed, keep both at the lowest effective doses and counsel patients and caregivers on seizure precautions.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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