Drug interactions
Amifampridine + Clomipramine
Severity: Moderate
Amifampridine and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine can cause dose-related seizures, and clomipramine lowers the seizure threshold. Using them together may increase the risk of seizures.
What this interaction means in plain words
Amifampridine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Additive lowering of seizure threshold: potassium channel blockade by amifampridine and proconvulsant effects of clomipramine.
What to do
Use the lowest effective doses and monitor for seizure activity. Consider an alternative antidepressant with lower seizure liability if the patient has a seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Clomipramine?
MediHelp rates the interaction as moderate. Amifampridine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine can cause dose-related seizures, and clomipramine lowers the seizure threshold. Using them together may increase the risk of seizures.
How serious is the interaction between Amifampridine and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for seizure activity. Consider an alternative antidepressant with lower seizure liability if the patient has a seizure history.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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