Drug interactions
Amifampridine + Fluvoxamine
Severity: Moderate
Amifampridine and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine causes dose-related seizures, and SSRIs such as fluvoxamine may lower seizure threshold. Combined use may increase seizure risk.
What this interaction means in plain words
Amifampridine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic lowering of seizure threshold.
What to do
Use the lowest effective amifampridine dose and monitor for seizure activity. Reassess the need for fluvoxamine in patients with seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Fluvoxamine?
MediHelp rates the interaction as moderate. Amifampridine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine causes dose-related seizures, and SSRIs such as fluvoxamine may lower seizure threshold. Combined use may increase seizure risk.
How serious is the interaction between Amifampridine and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective amifampridine dose and monitor for seizure activity. Reassess the need for fluvoxamine in patients with seizure history.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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