Drug interactions
Fluvoxamine + Mavacamten
Severity: Contraindicated
Fluvoxamine and Mavacamten: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolised largely by CYP2C19, which fluvoxamine strongly inhibits. Higher exposure can reduce ejection fraction and cause heart failure due to systolic dysfunction.
What this interaction means in plain words
Fluvoxamine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluvoxamine belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Why it happens
Fluvoxamine inhibits CYP2C19 (and CYP3A4) and reduces mavacamten clearance.
What to do
Avoid the combination and select another antidepressant. If fluvoxamine is started or stopped in a patient on mavacamten, monitor LVEF and adjust the dose per labeling.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
- Fluvoxamine + Phenelzine Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Mavacamten?
MediHelp rates the interaction as contraindicated. Fluvoxamine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mavacamten is metabolised largely by CYP2C19, which fluvoxamine strongly inhibits. Higher exposure can reduce ejection fraction and cause heart failure due to systolic dysfunction.
How serious is the interaction between Fluvoxamine and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select another antidepressant. If fluvoxamine is started or stopped in a patient on mavacamten, monitor LVEF and adjust the dose per labeling.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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