Drug interactions
Amifampridine + Gemifloxacin
Severity: Moderate
Amifampridine and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine dose-dependently lowers the seizure threshold, and fluoroquinolones such as gemifloxacin can also provoke seizures in susceptible patients. Using them together may raise the likelihood of convulsions.
What this interaction means in plain words
Amifampridine and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive lowering of seizure threshold (pharmacodynamic), likely via fluoroquinolone GABA-A antagonism and amifampridine potassium channel blockade.
What to do
Prefer a non-fluoroquinolone antibiotic in patients taking amifampridine, especially with a seizure history. If combined, monitor for neurological symptoms and review the amifampridine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amifampridine and Gemifloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Gemifloxacin?
MediHelp rates the interaction as moderate. Amifampridine and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine dose-dependently lowers the seizure threshold, and fluoroquinolones such as gemifloxacin can also provoke seizures in susceptible patients. Using them together may raise the likelihood of convulsions.
How serious is the interaction between Amifampridine and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-fluoroquinolone antibiotic in patients taking amifampridine, especially with a seizure history. If combined, monitor for neurological symptoms and review the amifampridine dose.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
