Drug interactions
Dofetilide + Gemifloxacin
Severity: Contraindicated
Dofetilide and Gemifloxacin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide has a strong, dose-related QT-prolonging effect and a narrow safety margin. Adding gemifloxacin increases the risk of torsades de pointes and fatal arrhythmias.
What this interaction means in plain words
Dofetilide and Gemifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive hERG potassium channel blockade prolonging ventricular repolarization.
What to do
Avoid concurrent use and select an antibiotic with no QT liability. If an antibiotic is essential, consult cardiology about continuous ECG monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
- Gemifloxacin + Ziprasidone Contraindicated
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Gemifloxacin?
MediHelp rates the interaction as contraindicated. Dofetilide and Gemifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dofetilide has a strong, dose-related QT-prolonging effect and a narrow safety margin. Adding gemifloxacin increases the risk of torsades de pointes and fatal arrhythmias.
How serious is the interaction between Dofetilide and Gemifloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select an antibiotic with no QT liability. If an antibiotic is essential, consult cardiology about continuous ECG monitoring.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Ibutilide, Pimozide. The full list is on the Gemifloxacin page.
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