Drug interactions
Amifampridine + Hydroxyzine
Severity: Minor
Amifampridine and Hydroxyzine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine has dose-dependent seizure risk, and agents that may lower seizure threshold could add to it. Hydroxyzine has limited seizure liability, so the interaction is mostly theoretical.
What this interaction means in plain words
Amifampridine and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amifampridine belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Possible additive lowering of seizure threshold; the effect is theoretical.
What to do
Use the lowest effective amifampridine dose and monitor for seizure activity, particularly in patients with a seizure history.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Hydroxyzine?
MediHelp rates the interaction as minor. Amifampridine and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amifampridine has dose-dependent seizure risk, and agents that may lower seizure threshold could add to it. Hydroxyzine has limited seizure liability, so the interaction is mostly theoretical.
How serious is the interaction between Amifampridine and Hydroxyzine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective amifampridine dose and monitor for seizure activity, particularly in patients with a seizure history.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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