Drug interactions
Amifampridine + Meperidine
Severity: Moderate
Amifampridine and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine can cause dose-related seizures, and meperidine's metabolite normeperidine is neuroexcitatory and can also lower the seizure threshold. Combined use may raise the risk of seizures, particularly in patients with renal impairment or high meperidine doses.
What this interaction means in plain words
Amifampridine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Additive lowering of seizure threshold through pharmacodynamic effects (potassium channel blockade by amifampridine, normeperidine accumulation with meperidine).
What to do
Prefer an opioid that does not form a neuroexcitatory metabolite. If meperidine must be used, keep doses and duration minimal and monitor for myoclonus or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Meperidine?
MediHelp rates the interaction as moderate. Amifampridine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine can cause dose-related seizures, and meperidine's metabolite normeperidine is neuroexcitatory and can also lower the seizure threshold. Combined use may raise the risk of seizures, particularly in patients with renal impairment or high meperidine doses.
How serious is the interaction between Amifampridine and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an opioid that does not form a neuroexcitatory metabolite. If meperidine must be used, keep doses and duration minimal and monitor for myoclonus or seizures.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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