Drug interactions
Meperidine + Procarbazine
Severity: Contraindicated
Meperidine and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO-inhibiting properties, and meperidine with MAO inhibitors can cause severe, sometimes fatal serotonin syndrome or excitatory reactions with hyperthermia. Meperidine is the opioid most associated with this reaction.
What this interaction means in plain words
Meperidine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Meperidine belongs to Musculoskeletal; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition combined with meperidine's serotonin reuptake inhibition leading to serotonin excess.
What to do
Do not use together or within 14 days of stopping an MAO inhibitor. Choose a non-serotonergic analgesic such as morphine, with monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Rasagiline Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Meperidine with Procarbazine?
MediHelp rates the interaction as contraindicated. Meperidine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting properties, and meperidine with MAO inhibitors can cause severe, sometimes fatal serotonin syndrome or excitatory reactions with hyperthermia. Meperidine is the opioid most associated with this reaction.
How serious is the interaction between Meperidine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping an MAO inhibitor. Choose a non-serotonergic analgesic such as morphine, with monitoring.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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