Drug interactions
Amifampridine + Moxifloxacin
Severity: Moderate
Amifampridine and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine causes dose-related seizures, and fluoroquinolones such as moxifloxacin can lower the seizure threshold. Combined use may increase the risk of seizures, particularly in patients with other risk factors.
What this interaction means in plain words
Amifampridine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive lowering of seizure threshold through pharmacodynamic effects (amifampridine potassium channel blockade and fluoroquinolone GABA-A antagonism).
What to do
Avoid the combination where an alternative antibiotic exists; otherwise monitor for seizure activity and use the lowest effective amifampridine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Moxifloxacin?
MediHelp rates the interaction as moderate. Amifampridine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine causes dose-related seizures, and fluoroquinolones such as moxifloxacin can lower the seizure threshold. Combined use may increase the risk of seizures, particularly in patients with other risk factors.
How serious is the interaction between Amifampridine and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antibiotic exists; otherwise monitor for seizure activity and use the lowest effective amifampridine dose.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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