Drug interactions
Dronedarone + Moxifloxacin
Severity: Contraindicated
Dronedarone and Moxifloxacin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval and dronedarone labeling contraindicates use with QT-prolonging drugs that may induce torsades de pointes. Together they markedly raise the risk of life-threatening arrhythmia.
What this interaction means in plain words
Dronedarone and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive blockade of cardiac potassium channels causing delayed repolarization.
What to do
Do not combine; use a non-QT-prolonging antibiotic during dronedarone therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
- Ibutilide + Moxifloxacin Contraindicated
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Moxifloxacin?
MediHelp rates the interaction as contraindicated. Dronedarone and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval and dronedarone labeling contraindicates use with QT-prolonging drugs that may induce torsades de pointes. Together they markedly raise the risk of life-threatening arrhythmia.
How serious is the interaction between Dronedarone and Moxifloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a non-QT-prolonging antibiotic during dronedarone therapy.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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