Drug interactions
Droperidol + Moxifloxacin
Severity: Contraindicated
Droperidol and Moxifloxacin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and moxifloxacin adds to that effect. Co-administration substantially raises the arrhythmia risk.
What this interaction means in plain words
Droperidol and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination and use a non-QT-prolonging antiemetic or antibiotic. If unavoidable, obtain an ECG and monitor continuously.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Ibutilide + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Droperidol with Moxifloxacin?
MediHelp rates the interaction as contraindicated. Droperidol and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and moxifloxacin adds to that effect. Co-administration substantially raises the arrhythmia risk.
How serious is the interaction between Droperidol and Moxifloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antiemetic or antibiotic. If unavoidable, obtain an ECG and monitor continuously.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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