Drug interactions
Amifampridine + Perphenazine
Severity: Moderate
Amifampridine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifampridine causes dose-related seizures, and phenothiazines such as perphenazine can lower the seizure threshold. Combined use may raise seizure risk.
What this interaction means in plain words
Amifampridine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive lowering of the seizure threshold through pharmacodynamic effects.
What to do
Monitor for seizure activity and use the lowest effective amifampridine dose. Consider an alternative antipsychotic with less seizure liability if seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Amifampridine
- Amifampridine + Bupropion-naltrexone Major
- Amantadine + Amifampridine Moderate
- Amifampridine + Amitriptyline Moderate
- Amifampridine + Baclofen Moderate
- Amifampridine + Bethanechol Moderate
- Amifampridine + Bromocriptine Moderate
Frequently asked questions
Can I take Amifampridine with Perphenazine?
MediHelp rates the interaction as moderate. Amifampridine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifampridine causes dose-related seizures, and phenothiazines such as perphenazine can lower the seizure threshold. Combined use may raise seizure risk.
How serious is the interaction between Amifampridine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for seizure activity and use the lowest effective amifampridine dose. Consider an alternative antipsychotic with less seizure liability if seizures occur.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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