Drug interactions
Ibutilide + Perphenazine
Severity: Contraindicated
Ibutilide and Perphenazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide causes pronounced QT prolongation and torsades de pointes, which phenothiazines may add to. The combination raises the risk of life-threatening arrhythmia.
What this interaction means in plain words
Ibutilide and Perphenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive blockade of repolarizing potassium currents causing QT prolongation.
What to do
Avoid ibutilide in patients receiving perphenazine; consider electrical cardioversion or another strategy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Perphenazine
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
- Amisulpride + Perphenazine Major
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Perphenazine?
MediHelp rates the interaction as contraindicated. Ibutilide and Perphenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide causes pronounced QT prolongation and torsades de pointes, which phenothiazines may add to. The combination raises the risk of life-threatening arrhythmia.
How serious is the interaction between Ibutilide and Perphenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ibutilide in patients receiving perphenazine; consider electrical cardioversion or another strategy.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Pimozide, Thioridazine, Adagrasib. The full list is on the Perphenazine page.
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