Drug interactions
Amiodarone + Perphenazine
Severity: Major
Amiodarone and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can prolong the QT interval and amiodarone adds to this effect, raising the risk of torsades de pointes. Amiodarone may also raise perphenazine levels by inhibiting CYP2D6.
What this interaction means in plain words
Amiodarone and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with CYP2D6 inhibition by amiodarone increasing perphenazine exposure.
What to do
Avoid if possible by selecting an antipsychotic with less QT effect. If combined, monitor ECG and electrolytes and consider lowering the perphenazine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amisulpride + Perphenazine Major
Frequently asked questions
Can I take Amiodarone with Perphenazine?
MediHelp rates the interaction as major. Amiodarone and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Perphenazine can prolong the QT interval and amiodarone adds to this effect, raising the risk of torsades de pointes. Amiodarone may also raise perphenazine levels by inhibiting CYP2D6.
How serious is the interaction between Amiodarone and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible by selecting an antipsychotic with less QT effect. If combined, monitor ECG and electrolytes and consider lowering the perphenazine dose.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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