Drug interactions
Amifostine + Amobarbital
Severity: Moderate
Amifostine and Amobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine frequently causes hypotension, and barbiturates can add to blood pressure lowering. Combined use may increase the risk of symptomatic hypotension.
What this interaction means in plain words
Amifostine and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Amobarbital belongs to Central Nervous System.
Why it happens
Additive hypotensive effects; barbiturates cause vasodilation and CNS-mediated blood pressure reduction.
What to do
Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider holding antihypertensives per amifostine labeling and treat hypotension promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Amobarbital?
MediHelp rates the interaction as moderate. Amifostine and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine frequently causes hypotension, and barbiturates can add to blood pressure lowering. Combined use may increase the risk of symptomatic hypotension.
How serious is the interaction between Amifostine and Amobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider holding antihypertensives per amifostine labeling and treat hypotension promptly.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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