Drug interactions
Amobarbital + Lonafarnib
Severity: Contraindicated
Amobarbital and Lonafarnib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate, so enzyme induction by amobarbital can greatly reduce its exposure. This could cause loss of efficacy. Labeling prohibits use with strong or moderate CYP3A inducers.
What this interaction means in plain words
Amobarbital and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amobarbital belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
Barbiturate-mediated CYP3A4 induction increases lonafarnib metabolism.
What to do
Avoid the combination. Select a non-inducing alternative to amobarbital.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lorlatinib Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
- Crizotinib + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Lonafarnib?
MediHelp rates the interaction as contraindicated. Amobarbital and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, so enzyme induction by amobarbital can greatly reduce its exposure. This could cause loss of efficacy. Labeling prohibits use with strong or moderate CYP3A inducers.
How serious is the interaction between Amobarbital and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Select a non-inducing alternative to amobarbital.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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