Drug interactions
Amifostine + Bosentan
Severity: Moderate
Amifostine and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and bosentan also lowers blood pressure through vasodilation. Together they may produce additive, potentially significant hypotension.
What this interaction means in plain words
Amifostine and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Bosentan belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic blood pressure lowering.
What to do
When amifostine is given at chemotherapy doses, hold bosentan for 24 hours beforehand if feasible, and monitor blood pressure during the infusion. If antihypertensive therapy cannot be withheld, do not give amifostine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Bosentan?
MediHelp rates the interaction as moderate. Amifostine and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and bosentan also lowers blood pressure through vasodilation. Together they may produce additive, potentially significant hypotension.
How serious is the interaction between Amifostine and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When amifostine is given at chemotherapy doses, hold bosentan for 24 hours beforehand if feasible, and monitor blood pressure during the infusion. If antihypertensive therapy cannot be withheld, do not give amifostine.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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