Drug interactions
Amifostine + Brexpiprazole
Severity: Moderate
Amifostine and Brexpiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension and brexpiprazole can cause orthostatic hypotension through alpha-1 blockade. Together they may produce additive blood pressure lowering, dizziness or syncope.
What this interaction means in plain words
Amifostine and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Brexpiprazole belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of amifostine and alpha-1 adrenergic antagonism of brexpiprazole.
What to do
Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider holding antihypertensive therapy as directed by amifostine labeling and take care with brexpiprazole timing around infusions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Brexpiprazole?
MediHelp rates the interaction as moderate. Amifostine and Brexpiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension and brexpiprazole can cause orthostatic hypotension through alpha-1 blockade. Together they may produce additive blood pressure lowering, dizziness or syncope.
How serious is the interaction between Amifostine and Brexpiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider holding antihypertensive therapy as directed by amifostine labeling and take care with brexpiprazole timing around infusions.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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