Drug interactions
Amifostine + Eplerenone
Severity: Moderate
Amifostine and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and eplerenone has blood pressure lowering effects. Together they may increase the frequency and severity of hypotension during amifostine infusion. At chemotherapy doses, labeling advises that antihypertensives be withheld beforehand.
What this interaction means in plain words
Amifostine and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Eplerenone belongs to Cardiovascular.
Why it happens
Additive hypotensive effects (pharmacodynamic synergism).
What to do
At chemotherapeutic amifostine doses, hold eplerenone for 24 hours before infusion where possible. If it cannot be held, do not give amifostine, and monitor blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amifostine and Eplerenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Eplerenone?
MediHelp rates the interaction as moderate. Amifostine and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and eplerenone has blood pressure lowering effects. Together they may increase the frequency and severity of hypotension during amifostine infusion. At chemotherapy doses, labeling advises that antihypertensives be withheld beforehand.
How serious is the interaction between Amifostine and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: At chemotherapeutic amifostine doses, hold eplerenone for 24 hours before infusion where possible. If it cannot be held, do not give amifostine, and monitor blood pressure closely.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
