Drug interactions
Ensitrelvir + Eplerenone
Severity: Contraindicated
Ensitrelvir and Eplerenone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ensitrelvir increases eplerenone exposure by inhibiting CYP3A. Higher levels raise the risk of hyperkalemia and related cardiac effects.
What this interaction means in plain words
Ensitrelvir and Eplerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ensitrelvir belongs to Anti Virals; Eplerenone belongs to Cardiovascular.
Why it happens
CYP3A inhibition reduces eplerenone clearance.
What to do
Do not use together; choose an alternative COVID-19 therapy or hold eplerenone only under clinician direction with potassium monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ensitrelvir
- Apalutamide + Ensitrelvir Contraindicated
- Carbamazepine + Ensitrelvir Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Ensitrelvir + Ivabradine Contraindicated
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Ensitrelvir with Eplerenone?
MediHelp rates the interaction as contraindicated. Ensitrelvir and Eplerenone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ensitrelvir increases eplerenone exposure by inhibiting CYP3A. Higher levels raise the risk of hyperkalemia and related cardiac effects.
How serious is the interaction between Ensitrelvir and Eplerenone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an alternative COVID-19 therapy or hold eplerenone only under clinician direction with potassium monitoring.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Colchicine. The full list is on the Ensitrelvir page.
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