Drug interactions
Amifostine + Lurasidone
Severity: Moderate
Amifostine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and lurasidone adds alpha-1 blockade that may worsen it. The combination could cause significant blood pressure falls around chemotherapy infusions.
What this interaction means in plain words
Amifostine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects: amifostine-related hypotension plus alpha-1 adrenergic antagonism by lurasidone.
What to do
Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider holding or adjusting antihypertensives and be alert to orthostatic symptoms with lurasidone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Lurasidone?
MediHelp rates the interaction as moderate. Amifostine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and lurasidone adds alpha-1 blockade that may worsen it. The combination could cause significant blood pressure falls around chemotherapy infusions.
How serious is the interaction between Amifostine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure before and during amifostine infusion and ensure adequate hydration. Consider holding or adjusting antihypertensives and be alert to orthostatic symptoms with lurasidone.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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