Drug interactions
Conivaptan + Lurasidone
Severity: Contraindicated
Conivaptan and Lurasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a potent CYP3A4 inhibitor and can markedly raise lurasidone exposure. Higher levels increase the risk of sedation, extrapyramidal symptoms, akathisia and other dose-related adverse effects. Lurasidone labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Conivaptan and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lurasidone in the liver and gut wall.
What to do
Avoid the combination; if conivaptan is needed, consider an alternative antipsychotic or an alternative treatment for hyponatremia.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Darunavir + Lurasidone Contraindicated
Frequently asked questions
Can I take Conivaptan with Lurasidone?
MediHelp rates the interaction as contraindicated. Conivaptan and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a potent CYP3A4 inhibitor and can markedly raise lurasidone exposure. Higher levels increase the risk of sedation, extrapyramidal symptoms, akathisia and other dose-related adverse effects. Lurasidone labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Conivaptan and Lurasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if conivaptan is needed, consider an alternative antipsychotic or an alternative treatment for hyponatremia.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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