Drug interactions
Amifostine + Torsemide
Severity: Moderate
Amifostine and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amifostine commonly causes hypotension, and a loop diuretic with volume-depleting and blood pressure lowering effects can make this worse. The risk is greatest with chemotherapy-level amifostine doses.
What this interaction means in plain words
Amifostine and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifostine belongs to Miscellaneous; Torsemide belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through pharmacodynamic synergism, with diuretic-induced volume depletion adding to amifostine hypotension.
What to do
At chemotherapeutic amifostine doses, hold torsemide for 24 hours beforehand; if it cannot be held, do not give amifostine. At lower doses, ensure adequate hydration and monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amifostine and Torsemide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Torsemide
Other interactions of Amifostine
Frequently asked questions
Can I take Amifostine with Torsemide?
MediHelp rates the interaction as moderate. Amifostine and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amifostine commonly causes hypotension, and a loop diuretic with volume-depleting and blood pressure lowering effects can make this worse. The risk is greatest with chemotherapy-level amifostine doses.
How serious is the interaction between Amifostine and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: At chemotherapeutic amifostine doses, hold torsemide for 24 hours beforehand; if it cannot be held, do not give amifostine. At lower doses, ensure adequate hydration and monitor blood pressure.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
