Drug interactions
Carbenoxolone + Torsemide
Severity: Major
Carbenoxolone and Torsemide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity causing sodium and water retention and potassium loss. With torsemide, hypokalemia can be pronounced and the diuretic effect may be opposed.
What this interaction means in plain words
Carbenoxolone and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, giving mineralocorticoid excess that adds to loop diuretic potassium wasting.
What to do
Avoid the combination where possible. If used together, monitor serum potassium and blood pressure closely and replace potassium as required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Torsemide
Frequently asked questions
Can I take Carbenoxolone with Torsemide?
MediHelp rates the interaction as major. Carbenoxolone and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity causing sodium and water retention and potassium loss. With torsemide, hypokalemia can be pronounced and the diuretic effect may be opposed.
How serious is the interaction between Carbenoxolone and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used together, monitor serum potassium and blood pressure closely and replace potassium as required.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Chlorthalidone. The full list is on the Torsemide page.
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