Drug interactions
Amikacin + Cefotetan
Severity: Moderate
Amikacin and Cefotetan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of an aminoglycoside and a cephalosporin has been associated with greater nephrotoxicity in some reports. The risk is mostly in patients with existing renal impairment, dehydration or prolonged therapy.
What this interaction means in plain words
Amikacin and Cefotetan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefotetan belongs to Anti Bacterial.
Why it happens
Possible additive renal tubular toxicity.
What to do
Monitor serum creatinine during therapy and measure amikacin levels. Adjust doses for renal function and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amikacin and Cefotetan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Other interactions of Cefotetan
- Cefotetan + Dronabinol Contraindicated
- Cefotetan + Warfarin Major
- Argatroban + Cefotetan Moderate
- Cefotetan + Dalteparin Moderate
- Cefotetan + Enoxaparin Moderate
- Cefotetan + Fondaparinux Moderate
Frequently asked questions
Can I take Amikacin with Cefotetan?
MediHelp rates the interaction as moderate. Amikacin and Cefotetan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of an aminoglycoside and a cephalosporin has been associated with greater nephrotoxicity in some reports. The risk is mostly in patients with existing renal impairment, dehydration or prolonged therapy.
How serious is the interaction between Amikacin and Cefotetan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine during therapy and measure amikacin levels. Adjust doses for renal function and maintain hydration.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
