Drug interactions
Cefotetan + Dalteparin
Severity: Moderate
Cefotetan and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefotetan can cause hypoprothrombinemia and platelet dysfunction, which may add to the anticoagulant effect of dalteparin. Bleeding risk is greater with poor nutrition, prolonged therapy or renal impairment.
What this interaction means in plain words
Cefotetan and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotetan belongs to Anti Bacterial; Dalteparin belongs to Cardiovascular.
Why it happens
Additive hemostatic effects: the N-methylthiotetrazole side chain of cefotetan interferes with vitamin K-dependent clotting factor synthesis and platelet function.
What to do
Monitor for bleeding and check PT/INR and platelet count in prolonged courses; give vitamin K if coagulopathy develops or choose an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cefotetan and Dalteparin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Cefotetan
- Cefotetan + Dronabinol Contraindicated
- Cefotetan + Warfarin Major
- Amikacin + Cefotetan Moderate
- Argatroban + Cefotetan Moderate
- Cefotetan + Enoxaparin Moderate
- Cefotetan + Fondaparinux Moderate
Frequently asked questions
Can I take Cefotetan with Dalteparin?
MediHelp rates the interaction as moderate. Cefotetan and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefotetan can cause hypoprothrombinemia and platelet dysfunction, which may add to the anticoagulant effect of dalteparin. Bleeding risk is greater with poor nutrition, prolonged therapy or renal impairment.
How serious is the interaction between Cefotetan and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check PT/INR and platelet count in prolonged courses; give vitamin K if coagulopathy develops or choose an alternative antibiotic.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
