Drug interactions
Amikacin + Celecoxib
Severity: Moderate
Amikacin and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce aminoglycoside clearance and raise levels, described mainly in preterm infants. Both agents can affect the kidney, so combined use raises nephrotoxicity risk.
What this interaction means in plain words
Amikacin and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Celecoxib belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis lowers renal perfusion and glomerular filtration, decreasing amikacin clearance.
What to do
Monitor amikacin levels and serum creatinine and adjust dosing accordingly. Avoid the combination in neonates and in patients with renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Celecoxib?
MediHelp rates the interaction as moderate. Amikacin and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce aminoglycoside clearance and raise levels, described mainly in preterm infants. Both agents can affect the kidney, so combined use raises nephrotoxicity risk.
How serious is the interaction between Amikacin and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor amikacin levels and serum creatinine and adjust dosing accordingly. Avoid the combination in neonates and in patients with renal impairment where possible.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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