Drug interactions
Amikacin + Diclofenac
Severity: Moderate
Amikacin and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, raising amikacin concentrations and the risk of nephrotoxicity and ototoxicity. This has been best described in preterm neonates but renal risk also applies to adults with reduced kidney function.
What this interaction means in plain words
Amikacin and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Diclofenac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins lowers glomerular filtration, reducing aminoglycoside elimination, in addition to additive nephrotoxicity.
What to do
Monitor amikacin serum levels and renal function when combined, especially in neonates, the elderly or renal impairment. Prefer an alternative analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Diclofenac?
MediHelp rates the interaction as moderate. Amikacin and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of aminoglycosides, raising amikacin concentrations and the risk of nephrotoxicity and ototoxicity. This has been best described in preterm neonates but renal risk also applies to adults with reduced kidney function.
How serious is the interaction between Amikacin and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor amikacin serum levels and renal function when combined, especially in neonates, the elderly or renal impairment. Prefer an alternative analgesic where possible.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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