Drug interactions
Amikacin + Diflunisal
Severity: Moderate
Amikacin and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, a effect best documented in preterm neonates given indomethacin or ibuprofen. In adults the effect is less well defined but renal toxicity may be additive.
What this interaction means in plain words
Amikacin and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Diflunisal belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction of renal prostaglandins and glomerular filtration lowers aminoglycoside clearance.
What to do
Monitor amikacin serum concentrations and renal function when an NSAID is co-prescribed, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Diflunisal?
MediHelp rates the interaction as moderate. Amikacin and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of aminoglycosides, a effect best documented in preterm neonates given indomethacin or ibuprofen. In adults the effect is less well defined but renal toxicity may be additive.
How serious is the interaction between Amikacin and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor amikacin serum concentrations and renal function when an NSAID is co-prescribed, adjusting the dose as needed.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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