Drug interactions
Amikacin + Etodolac
Severity: Moderate
Amikacin and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, with raised levels documented chiefly in preterm neonates. In adults the effect is less well established, but both drugs can affect the kidney.
What this interaction means in plain words
Amikacin and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Etodolac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins lowers glomerular filtration and aminoglycoside clearance.
What to do
Monitor amikacin serum concentrations and renal function when the NSAID is used, especially in neonates or patients with renal impairment. Adjust the aminoglycoside dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Etodolac?
MediHelp rates the interaction as moderate. Amikacin and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of aminoglycosides, with raised levels documented chiefly in preterm neonates. In adults the effect is less well established, but both drugs can affect the kidney.
How serious is the interaction between Amikacin and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor amikacin serum concentrations and renal function when the NSAID is used, especially in neonates or patients with renal impairment. Adjust the aminoglycoside dose accordingly.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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