Drug interactions
Amikacin + Indomethacin
Severity: Moderate
Amikacin and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin given to preterm infants, for example for patent ductus arteriosus closure, has been associated with raised aminoglycoside concentrations. The reduction in renal function can lead to higher amikacin exposure and increased nephrotoxicity and ototoxicity risk.
What this interaction means in plain words
Amikacin and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Indomethacin belongs to Musculoskeletal.
Why it happens
Indomethacin-induced inhibition of renal prostaglandins reduces glomerular filtration and aminoglycoside clearance.
What to do
Monitor amikacin serum concentrations and serum creatinine, and adjust the dose or interval in neonates and patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Indomethacin?
MediHelp rates the interaction as moderate. Amikacin and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin given to preterm infants, for example for patent ductus arteriosus closure, has been associated with raised aminoglycoside concentrations. The reduction in renal function can lead to higher amikacin exposure and increased nephrotoxicity and ototoxicity risk.
How serious is the interaction between Amikacin and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor amikacin serum concentrations and serum creatinine, and adjust the dose or interval in neonates and patients with renal impairment.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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