Drug interactions
Amikacin + Ketoprofen
Severity: Moderate
Amikacin and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal prostaglandin-dependent perfusion and glomerular filtration, which may slow aminoglycoside clearance. This has been described mainly in preterm infants given indomethacin or ibuprofen, and raises the risk of aminoglycoside accumulation, nephrotoxicity and ototoxicity. Data for ketoprofen are limited and extrapolated.
What this interaction means in plain words
Amikacin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal blood flow and glomerular filtration decreases aminoglycoside elimination, with additive nephrotoxic potential.
What to do
Monitor serum amikacin concentrations and renal function when the combination is used, especially in neonates, older adults or those with renal impairment. Adjust the amikacin dose based on levels and consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ketoprofen?
MediHelp rates the interaction as moderate. Amikacin and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal prostaglandin-dependent perfusion and glomerular filtration, which may slow aminoglycoside clearance. This has been described mainly in preterm infants given indomethacin or ibuprofen, and raises the risk of aminoglycoside accumulation, nephrotoxicity and ototoxicity. Data for ketoprofen are limited and extrapolated.
How serious is the interaction between Amikacin and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum amikacin concentrations and renal function when the combination is used, especially in neonates, older adults or those with renal impairment. Adjust the amikacin dose based on levels and consider an alternative analgesic.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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