Drug interactions
Amikacin + Oxaprozin
Severity: Moderate
Amikacin and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, raising serum levels and potential nephrotoxicity and ototoxicity. This has been described chiefly in preterm neonates, and NSAIDs are themselves nephrotoxic in at-risk patients.
What this interaction means in plain words
Amikacin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular filtration and aminoglycoside clearance.
What to do
Monitor serum amikacin concentrations and renal function when an NSAID is co-administered, especially in neonates, older adults or renal impairment. Avoid the NSAID if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Oxaprozin?
MediHelp rates the interaction as moderate. Amikacin and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal clearance of aminoglycosides, raising serum levels and potential nephrotoxicity and ototoxicity. This has been described chiefly in preterm neonates, and NSAIDs are themselves nephrotoxic in at-risk patients.
How serious is the interaction between Amikacin and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum amikacin concentrations and renal function when an NSAID is co-administered, especially in neonates, older adults or renal impairment. Avoid the NSAID if possible.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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