Drug interactions
Amikacin + Sulindac
Severity: Moderate
Amikacin and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal prostaglandin-dependent perfusion and increase aminoglycoside concentrations, a effect described mainly in preterm neonates given indomethacin or ibuprofen. In adults the effect is less well established but additive nephrotoxicity is possible.
What this interaction means in plain words
Amikacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Reduced renal blood flow and glomerular filtration from NSAID prostaglandin inhibition decreases aminoglycoside clearance.
What to do
Monitor serum creatinine and amikacin trough levels when both are used. Maintain hydration and adjust the aminoglycoside dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Sulindac?
MediHelp rates the interaction as moderate. Amikacin and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal prostaglandin-dependent perfusion and increase aminoglycoside concentrations, a effect described mainly in preterm neonates given indomethacin or ibuprofen. In adults the effect is less well established but additive nephrotoxicity is possible.
How serious is the interaction between Amikacin and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin trough levels when both are used. Maintain hydration and adjust the aminoglycoside dose to renal function.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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