Drug interactions
Amiloride + Dalteparin
Severity: Moderate
Amiloride and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Low molecular weight heparins can suppress aldosterone synthesis and cause hyperkalemia, which adds to the potassium-retaining effect of amiloride. The risk rises with prolonged therapy, renal impairment or diabetes.
What this interaction means in plain words
Amiloride and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Dalteparin inhibits adrenal aldosterone secretion, and amiloride independently reduces renal potassium excretion.
What to do
Monitor serum potassium, especially if treatment lasts more than several days or renal function is reduced. Stop amiloride if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Amiloride with Dalteparin?
MediHelp rates the interaction as moderate. Amiloride and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Low molecular weight heparins can suppress aldosterone synthesis and cause hyperkalemia, which adds to the potassium-retaining effect of amiloride. The risk rises with prolonged therapy, renal impairment or diabetes.
How serious is the interaction between Amiloride and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially if treatment lasts more than several days or renal function is reduced. Stop amiloride if hyperkalemia develops.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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