Drug interactions
Amiloride + Ethacrynic acid
Severity: Minor
Amiloride and Ethacrynic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride is often combined with loop diuretics to limit potassium loss and enhance diuresis. Ethacrynic acid promotes potassium excretion and the two effects counterbalance, but fluid and electrolyte disturbances, including hypovolemia, hyponatremia or hyperkalemia, may still occur.
What this interaction means in plain words
Amiloride and Ethacrynic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Ethacrynic acid inhibits the Na-K-2Cl cotransporter and increases potassium loss, while amiloride blocks ENaC and conserves potassium.
What to do
Monitor serum electrolytes and renal function and adjust the doses of each agent to the potassium result.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Amiloride with Ethacrynic acid?
MediHelp rates the interaction as minor. Amiloride and Ethacrynic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiloride is often combined with loop diuretics to limit potassium loss and enhance diuresis. Ethacrynic acid promotes potassium excretion and the two effects counterbalance, but fluid and electrolyte disturbances, including hypovolemia, hyponatremia or hyperkalemia, may still occur.
How serious is the interaction between Amiloride and Ethacrynic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum electrolytes and renal function and adjust the doses of each agent to the potassium result.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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