Drug interactions
Azilsartan-chlorthalidone + Ethacrynic acid
Severity: Major
Azilsartan-chlorthalidone and Ethacrynic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic and combining it with a thiazide-like diuretic produces sequential nephron blockade. This can cause profound diuresis with marked hypokalemia, hyponatremia, hypomagnesemia, volume depletion and kidney injury.
What this interaction means in plain words
Azilsartan-chlorthalidone and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Sequential blockade of sodium reabsorption in the loop of Henle and distal tubule produces synergistic natriuresis and potassium wasting.
What to do
Start with low doses and monitor weight, blood pressure, electrolytes and renal function closely. Replace potassium and magnesium as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Ethacrynic acid?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethacrynic acid is a potent loop diuretic and combining it with a thiazide-like diuretic produces sequential nephron blockade. This can cause profound diuresis with marked hypokalemia, hyponatremia, hypomagnesemia, volume depletion and kidney injury.
How serious is the interaction between Azilsartan-chlorthalidone and Ethacrynic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor weight, blood pressure, electrolytes and renal function closely. Replace potassium and magnesium as needed.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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