Drug interactions
Captopril-hydrochlorothiazide + Ethacrynic acid
Severity: Major
Captopril-hydrochlorothiazide and Ethacrynic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic that, with hydrochlorothiazide, produces sequential nephron blockade with marked diuresis and loss of potassium, sodium and magnesium. Together with an ACE inhibitor this may cause severe hypotension and acute kidney injury, particularly in volume-depleted patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive natriuresis and electrolyte wasting from loop and thiazide diuretics, plus ACE inhibitor reduction of glomerular filtration pressure in volume depletion.
What to do
Monitor blood pressure, volume status, electrolytes and creatinine closely, particularly in the first days. Reduce or hold the diuretics if hypotension, hypokalemia or rising creatinine occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Ethacrynic acid?
MediHelp rates the interaction as major. Captopril-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethacrynic acid is a potent loop diuretic that, with hydrochlorothiazide, produces sequential nephron blockade with marked diuresis and loss of potassium, sodium and magnesium. Together with an ACE inhibitor this may cause severe hypotension and acute kidney injury, particularly in volume-depleted patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Ethacrynic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, electrolytes and creatinine closely, particularly in the first days. Reduce or hold the diuretics if hypotension, hypokalemia or rising creatinine occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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