Drug interactions
Amiloride + Furosemide
Severity: Moderate
Amiloride and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide promotes potassium loss while amiloride retains it, so the combination is often used deliberately to balance potassium. Potassium may still become too high or too low, particularly with renal impairment or changing diuretic doses.
What this interaction means in plain words
Amiloride and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Opposing effects on renal potassium handling: loop diuretic kaliuresis versus amiloride ENaC blockade in the collecting duct.
What to do
Monitor serum potassium, sodium and renal function regularly, especially after dose changes. Adjust the doses to keep potassium in range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Furosemide?
MediHelp rates the interaction as moderate. Amiloride and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide promotes potassium loss while amiloride retains it, so the combination is often used deliberately to balance potassium. Potassium may still become too high or too low, particularly with renal impairment or changing diuretic doses.
How serious is the interaction between Amiloride and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium and renal function regularly, especially after dose changes. Adjust the doses to keep potassium in range.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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