Drug interactions
Cisplatin + Furosemide
Severity: Major
Cisplatin and Furosemide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can damage the cochlea, and loop diuretics given with cisplatin increase the risk of hearing loss and tinnitus, which may be permanent. Furosemide can also worsen cisplatin-related nephrotoxicity through volume depletion and electrolyte loss.
What this interaction means in plain words
Cisplatin and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Furosemide belongs to Cardiovascular.
Why it happens
Additive ototoxicity affecting cochlear hair cells and the stria vascularis, plus additive renal and electrolyte effects.
What to do
Avoid routine concurrent use where possible and use furosemide only when needed for hydration-related volume overload. Obtain audiometry and monitor renal function, magnesium and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Digoxin + Furosemide Major
- Ethacrynic acid + Furosemide Major
Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Cisplatin with Furosemide?
MediHelp rates the interaction as major. Cisplatin and Furosemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the cochlea, and loop diuretics given with cisplatin increase the risk of hearing loss and tinnitus, which may be permanent. Furosemide can also worsen cisplatin-related nephrotoxicity through volume depletion and electrolyte loss.
How serious is the interaction between Cisplatin and Furosemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use where possible and use furosemide only when needed for hydration-related volume overload. Obtain audiometry and monitor renal function, magnesium and potassium.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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