Drug interactions
Amiloride + Magnesium hydroxide
Severity: Minor
Amiloride and Magnesium hydroxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride reduces urinary magnesium excretion, so magnesium levels may rise slightly. This is generally of little concern with normal kidney function, but may matter in renal impairment with regular magnesium antacid use.
What this interaction means in plain words
Amiloride and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Amiloride lowers renal magnesium excretion by blocking distal sodium channels.
What to do
Monitor serum magnesium in patients with renal impairment who take magnesium products regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium hydroxide
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Magnesium hydroxide?
MediHelp rates the interaction as minor. Amiloride and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiloride reduces urinary magnesium excretion, so magnesium levels may rise slightly. This is generally of little concern with normal kidney function, but may matter in renal impairment with regular magnesium antacid use.
How serious is the interaction between Amiloride and Magnesium hydroxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium in patients with renal impairment who take magnesium products regularly.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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