Drug interactions
Magnesium hydroxide + Moxifloxacin
Severity: Major
Magnesium hydroxide and Moxifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium cations bind moxifloxacin in the gut and reduce its absorption, potentially lowering antibiotic effectiveness.
What this interaction means in plain words
Magnesium hydroxide and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Magnesium hydroxide belongs to Gastrointestinal Tract; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Chelation of moxifloxacin by magnesium cations in the gastrointestinal tract reduces absorption.
What to do
Give moxifloxacin at least 4 hours before or 8 hours after magnesium hydroxide, per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Magnesium hydroxide
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Magnesium hydroxide with Moxifloxacin?
MediHelp rates the interaction as major. Magnesium hydroxide and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium cations bind moxifloxacin in the gut and reduce its absorption, potentially lowering antibiotic effectiveness.
How serious is the interaction between Magnesium hydroxide and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give moxifloxacin at least 4 hours before or 8 hours after magnesium hydroxide, per labeling.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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