Drug interactions
Dolutegravir + Magnesium hydroxide
Severity: Major
Dolutegravir and Magnesium hydroxide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium binds dolutegravir in the gut and substantially lowers its absorption. Reduced exposure may cause virologic failure and integrase resistance.
What this interaction means in plain words
Dolutegravir and Magnesium hydroxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolutegravir belongs to Anti Virals; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Chelation of dolutegravir by polyvalent magnesium cations in the gastrointestinal tract.
What to do
Take dolutegravir 2 hours before or 6 hours after magnesium hydroxide. Monitor viral load if timing cannot be maintained.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Magnesium hydroxide
Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Magnesium hydroxide?
MediHelp rates the interaction as major. Dolutegravir and Magnesium hydroxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium binds dolutegravir in the gut and substantially lowers its absorption. Reduced exposure may cause virologic failure and integrase resistance.
How serious is the interaction between Dolutegravir and Magnesium hydroxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take dolutegravir 2 hours before or 6 hours after magnesium hydroxide. Monitor viral load if timing cannot be maintained.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Magnesium hydroxide page.
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