Drug interactions
Amiloride + Penicillin g
Severity: Moderate
Amiloride and Penicillin g: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aqueous penicillin G is given as the potassium salt, which delivers a significant potassium load, particularly at high doses. Amiloride reduces renal potassium excretion, so hyperkalemia can develop, especially in renal impairment.
What this interaction means in plain words
Amiloride and Penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Penicillin g belongs to Anti Bacterial.
Why it happens
Additive potassium load from penicillin G potassium with amiloride's inhibition of renal potassium secretion.
What to do
Monitor serum potassium and renal function, particularly with high-dose or prolonged penicillin G potassium. Consider a sodium salt of penicillin or stop amiloride if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
- Demeclocycline + Penicillin g Moderate
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Penicillin g?
MediHelp rates the interaction as moderate. Amiloride and Penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aqueous penicillin G is given as the potassium salt, which delivers a significant potassium load, particularly at high doses. Amiloride reduces renal potassium excretion, so hyperkalemia can develop, especially in renal impairment.
How serious is the interaction between Amiloride and Penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, particularly with high-dose or prolonged penicillin G potassium. Consider a sodium salt of penicillin or stop amiloride if hyperkalemia develops.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Bcg vaccine live, Cholera vaccine. The full list is on the Penicillin g page.
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